Zyban (Wellbutrin and bupropion) and Chantix (varenicline) are both prescription medications used to help individuals quit smoking. So, how do they work?

Zyban (Wellbutrin and Bupropion) is an antidepressant medication (Wellbutrin) that is also approved for smoking cessation. It is believed to work by blocking the reuptake of dopamine and norepinephrine, two neurotransmitters that play a role in mood regulation and are also involved in the brain’s reward system. By blocking the reuptake of these neurotransmitters, bupropion increases their levels in the brain, which can reduce the severity of withdrawal symptoms and cravings associated with quitting smoking.

The protocol for taking Zyban typically involves starting with a low dose and gradually increasing it over several days, usually to a target dose of 300 mg per day. This can be taken as a single daily dose or as two divided doses. The typical treatment course lasts 7-12 weeks. More details:

• The recommended dose of Zyban is 150 mg taken twice a day, with doses being taken 8 hours apart.
• Treatment with Zyban usually starts 7 to 14 days before the person’s quit date.
• The medication is usually taken for 7 to 12 weeks, but the treatment duration may be extended if needed.

Chantix (varenicline) is a prescription medication specifically approved for smoking cessation. It works by binding to nicotine receptors in the brain and reducing cravings for nicotine. It also partially stimulates these receptors, which can help to relieve withdrawal symptoms and reduce the pleasurable effects of nicotine, making it less rewarding to smoke.

The protocol for taking Chantix involves starting with a low dose and gradually increasing it over several days, typically to a target dose of 1 mg twice daily. The typical treatment course lasts 12 weeks. More details:

• The recommended dose of Chantix is 0.5 mg taken once daily for the first three days, followed by 0.5 mg twice a day for the next four days, and then 1 mg twice a day thereafter.
• Treatment with Chantix usually starts 1 week before the person’s quit date.
• The medication is usually taken for 12 weeks, but it may be continued for another 12 weeks for individuals who have successfully quit smoking.

It’s important to note that both Zyban and Chantix can cause severe and unsettling side effects and they can interact with other medications.

These medications should only be taken under the supervision of a healthcare provider, and individuals should follow their healthcare provider’s instructions regarding dosage and duration of treatment. It’s also important to inform the healthcare provider of any other medications you take, as well as any pre-existing medical conditions, as this may impact the use of these smoking cessation medications. Discuss your options with your healthcare provider to determine if they are appropriate for you and to understand any potential risks and benefits.